Spindle Poison Pharmacodynamics

Spindle poison pharmacodynamics – personalising therapy

The spindle assembly checkpoint (SAC) acts a safety switch that normally prevents erroneous cell division that can cause genomic instability. The SAC also plays a key role in mediating the effectiveness of drugs such as vinorelbine which we are investigating in relapsed mesothelioma in the CRUK VIM trial. Our work is exploring how the SAC is dysregulated in mesothelioma, with clear implications for how this pharmacology may be personalised for more effective therapy